Johnson & Johnson coronavirus vaccine gets better boost from Moderna or Pfizer, US study shows
- The findings by the National Institutes of Health come as an advisory group to the FDA prepares to discuss booster jabs for Moderna and J&J vaccines
- The preliminary study also showed that ‘mixing and matching’ booster shots of different types is safe in adults
The study, which included more than 450 adults who received initial shots from Pfizer, Moderna, or Johnson & Johnson, showed that “mixing and matching” booster shots of different types is safe in adults. Moderna’s and Pfizer’s vaccines are based on messenger RNA while J&J’s uses viral vector technology.
It comes as an advisory group to the US Food and Drug Administration is preparing to meet later this week to discuss the merits of a booster shot for Moderna and J&J vaccines.
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FDA officials on Wednesday said J&J’s regulatory submission for its planned booster raised red flags including small sample sizes and data based on tests that had not been validated.
The NIH study contrasted the safety and immune response of volunteers who were boosted with the same type of shot they had been given for their initial vaccination with those who received a different type of shot as a booster.
Mixing and matching doses for a booster produced similar side effects to those seen in primary inoculations and raised no significant safety concerns, the study said.
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The study of the three Covid-19 vaccines currently authorised in the United States showed that using different types of shots as boosters generally appeared to produce a comparable or higher antibody response than using the same type.
The trial took place in 10 US cities and used a total of nine combinations of initial shots and boosters.
Mixing booster doses “may offer immunological advantages to optimise the breadth and longevity of protection achieved with currently available vaccines”, researchers wrote in the study.
