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A group of men in the UK are the first in the world to test a new hormone-free male contraceptive pill.
Scientists hope that if the tests are successful, the daily pill could broaden shared responsibility for contraception between the sexes.
Men can currently only use condoms or have a vasectomy while there are a vast array of contraceptives for women including the pill, the coil, a contraceptive injection and use of diaphragms or female condoms, among other options.
The new male pill is a hormone-free drug, unlike the female pill.
Ugandan man with 102 children admits he has been ‘irresponsible’
The pill, YCT-529, is a drug called a retinoic acid receptor-alpha inhibitor, which prevents sperm production by blocking access to vitamin A.
Previous studies dating back more than 90 years have shown that depriving mice, rats and monkeys of vitamin A can cause infertility.
Experts from biopharmaceutical company YourChoice Therapeutics said that preclinical studies showed YCT-529 was “99 per cent effective and 100 per cent reversible with no side effects”.


The company said that previous versions of the male pill have attempted to suppress the male sex hormone testosterone to prevent sperm production, but this does not stop sperm production completely and has been linked to some complications.
Now, 16 men are testing the hormone-free pill in the UK. The phase 1 trial is being conducted by Quotient Sciences, a drug development company based in the English city of Nottingham.
“The last innovation in contraception was the birth control pill for women, and that’s more than 60 years ago,” said Gunda Georg, regents professor at the University of Minnesota’s College of Pharmacy, who developed the pill.
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“The world is ready for a male contraceptive agent, and delivering one that’s hormone-free is simply the right thing to do given what we know about the side effects women have endured for decades from the pill,” Georg said.
“We consciously chose to inhibit the vitamin A signalling pathway in the testis because nearly 100 years of research has validated this pathway and shows that infertility can be reversed easily,” she added.
“Our preclinical data is strong, showing that YCT-529 was 99 per cent effective in preventing mouse pregnancies and decreasing monkey sperm counts after two weeks of dosing. YCT-529 has also showed a strong safety profile, and full reversibility in mice and monkeys once treatment ended.”
The dearth of options reinforces the centuries-old view that pregnancy prevention is ‘a woman’s responsibility’
Akash Bakshi, YourChoice Therapeutics co-founder
Akash Bakshi, co-founder and chief executive of YourChoice Therapeutics, noted that YCT-529 blocks a protein – not hormones – to prevent sperm production.
“We believe this will be more attractive to men, most of whom view pregnancy prevention as a shared responsibility even despite today’s limited contraceptive options, which are permanent or only moderately effective,” he said.
“The dearth of options reinforces the centuries-old view that pregnancy prevention is ‘a woman’s responsibility’. It’s not, and we’re committed to advancing the first hormone-free birth control pill for men that’s effective, convenient and temporary.”


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Britain

UK begins test of hormone-free male contraceptive pill, so pregnancy prevention is not just a ‘woman’s responsibility’

Sixteen men in the UK will begin the world’s first test of a hormone-free male contraceptive pill, so pregnancy prevention is not just a ‘woman’s responsibility’. Photo: Shutterstock

US Supreme Court to rule on abortion pill access, in first case since it overturned Roe vs Wade

The Supreme Court has agreed to take up a dispute over a medication used in the most common method of abortion in the United States. It’s the court’s first abortion case since it overturned Roe v. Wade last year. Photo: AP

Mifepristone and misoprostol pills are used for medication abortions. Pill-induced abortion is the most common method for terminating a pregnancy in the US Photo: TNS

‘Have you bled yet?’: China doctor boyfriend secretly gives girlfriend abortion pills and sleeping tablets

A urologist in China is under investigation by the police after he told his pregnant girlfriend that he had spiked her drink with medicine to induce an abortion. Photo: Shutterstock

Surveillance footage shows the man stirring what is believed to be abortion medicine into a drink as he sits on a sofa in his girlfriend’s flat. Photo: Weibo

After he apologised for spiking her drink with abortion medicine and proposed to marry her, the woman did not report him to the police. Photo: Shutterstock

US FDA approves world’s first pill for post-partum depression

US health officials have approved the first pill, Zurzuvae, specifically intended to treat severe depression after childbirth. Photo: AP

First over-the-counter birth control pill in US gets FDA approval

The Food and Drug Administration said it has cleared Perrigo’s once-a-day Opill to be sold without a prescription. Photo: AP

Medical societies and women’s health groups have pushed for wider access, noting that an estimated 45 per cent of the 6 million annual pregnancies in the US are unintended. Photo: Shutterstock

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In preclinical studies – the pill known as YCT-529 – showed it was ‘99 per cent effective and 100 per cent reversible with no side effects’
The male pill is a hormone-free drug – unlike the female pill – and prevents sperm production by blocking access to vitamin A


The pill, YCT-529, is a hormone-free drug, unlike the female pill, and preclinical studies showed it was “99 per cent effective and 100 per cent reversible with no side effects”.


UK begins test of hormone-free male contraceptive pill, so pregnancy prevention is not just a ‘woman’s responsibility’

In preclinical studies – the pill known as YCT-529 – showed it was ‘99 per cent effective and 100 per cent reversible with no side effects’ The male pill is a hormone-free drug – unlike the female pill – and prevents sperm production by blocking access to vitamin A

In preclinical studies – the pill known as YCT-529 – showed it was ‘99 per cent effective and 100 per cent reversible with no side effects’

The male pill is a hormone-free drug – unlike the female pill – and prevents sperm production by blocking access to vitamin A