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Echo Xie

Guo Rui

He Jiankui, the Chinese scientist who created the world’s first gene-edited babies, has been freed after serving three years in prison.
When contacted by the South China Morning Post on Wednesday, he said “it’s not convenient to talk right now, thank you” and hung up.
He’s release was first reported by the MIT Technology Review on Monday, which said it had been confirmed by people familiar with the situation.
He sparked an international backlash when he announced in November 2018 at a conference in Hong Kong that he had created two genetically modified twin girls, “Lulu” and “Nana”. A third child, “Amy”, was born the following year.


He said he had used the gene-editing tool CRISPR-Cas9 to rewrite the DNA in their embryos to make them less susceptible to HIV, which their father had.
Critics said the disclosure had raised serious ethical concerns and also warned that the technology was far from being developed enough to be used for reproductive purposes.
He was fired from the Southern University of Science and Technology in Shenzhen, where he had been an associate professor, in January 2019.
He was placed under home arrest and then officially detained that year before being sentenced to three years in jail and fined 3 million yuan (US$470,000) for conducting “illegal medical practices” in December.
The scandal prompted China to tighten its regulations on human gene editing.
Draft regulations released in 2019 require national-level approval for clinical research involving gene-editing and other “high-risk biomedical technologies”.
Designer babies: Chinese scientist ‘may have created unintended mutations’
The Chinese government also released new guidelines ahead of He’s release to improve the ethical review process for fields such as life sciences and medicine.
The new guidelines, released late last month, called for an ethical review and regulatory system and stronger laws covering key areas such as life sciences, medicine and artificial intelligence.
Earlier in February, two prominent bioethicists called on the Chinese government to ensure they protected the interests of the gene-edited children and any descendants they may have.
Eben Kirksey, an associate professor at the Alfred Deakin Institute in Australia, said now was a chance to reflect on whether investing medical resources in “profit-driven” research using advanced technology such as CRISPR was the best way of meeting patients’ needs.


“He Jiankui’s experiment was the result of an extensive international network that connected his lab in Shenzhen to scientists and investors in California, Texas, New York and Boston.
“Over the past three years many companies have developed many lucrative applications of CRISPR gene-editing technologies, but many of these profit-driven ventures have taken attention away from patient communities,” he said.
Chinese researchers ‘delete’ memories from rats with CRISPR gene editing
“While HIV infections no longer present serious medical problems, at least in countries like China and the United States where medicine is readily available, the communities of patients who live with this virus still experience serious social stigma.”
The patients who signed up for He’s experiment were desperate to have children, but Chinese law prevented them from using reproductive technologies such as IVF because they suffered from a sexually transmitted disease, he added.
“Now is a chance for reflection on how to distribute resources in society. Should we be investing in cutting-edge research with CRISPR, or should we invest in medical and social interventions that are better aligned with the needs of patients?” Kirksey said.


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Science

Chinese scientist at centre of gene-editing baby scandal freed from jail

He Jiankui announced the babies’ birth in Hong Kong in 2018. Photo: SCMP

‘We should be prepared’: bioethicists look at how to care for China’s gene-edited babies

Bioethicist Qiu Renzong said there was a need to consider the ethical issues and be prepared. Photo: AFP

Scientist He Jiankui was jailed for his experiment, which drew global condemnation. Photo: AFP

Gene editing: Chinese scientists bring safer pig-to-human organ transplants one step closer to reality

Transplants from pigs have long been explored as a solution to the global shortage of human organs for patients with organ failure. Photo: Reuters

China’s gene-editing ‘Frankenstein’ jailed for three years in modified baby case

Chinese biologist He Jiankui has been jailed for his controversial experiments on human babies. Photo: Sam Tsang

News

China


He Jiankui announced the birth of three children whose genes had been modified with the goal of protecting them from HIV in 2018
The Shenzhen-based scientist triggered a backlash at home and abroad and was later handed a 3-year jail sentence



He Jiankui announced the birth of three children whose genes had been modified with the goal of protecting them from HIV in 2018.


Crime

Future tech

Medicine

Chinese scientist at centre of gene-editing baby scandal freed from jail

He Jiankui announced the birth of three children whose genes had been modified with the goal of protecting them from HIV in 2018 The Shenzhen-based scientist triggered a backlash at home and abroad and was later handed a 3-year jail sentence

He Jiankui announced the birth of three children whose genes had been modified with the goal of protecting them from HIV in 2018

The Shenzhen-based scientist triggered a backlash at home and abroad and was later handed a 3-year jail sentence