Who are Princess Charlotte and Prince Alexandre of Nassau, who just lost their brother Frederik? The Luxembourg royals are mourning the death of their sibling, and will carry on his NGO work

Princess Charlotte of Nassau’s year began on a happy note with a new job at Chanel and her wedding to Mansour Shakarchi, but now she’s mourning the death of her ‘valiant’ 22-year-old brother
Prince Frederik of Luxembourg, the youngest son of the Prince and Princess of Nassau, has died after a long battle with POLG mitochondrial disease, a rare genetic disorder.
The 22-year-old’s death was announced by his family on March 7 on the POLG Foundation website, started by Frederik in 2022.
“It is with a very heavy heart that my wife and I would like to inform you of the passing of our son, The POLG Foundation founder and creative director, Frederik,” his father, Prince Robert of Luxembourg, wrote.

“Last Friday, February 28, on ‘Rare Disease Day’, our beloved son called us in to his room to speak to him for one last time. Frederik found the strength and the courage to say goodbye to each of us in turn – his brother, Alexandre; his sister, Charlotte; me,” the bereaved father continued. “He had already spoken all that was in his heart to his extraordinary mother, who had not left his side in 15 years.”
According to the foundation’s website, POLG mitochondrial disease “is a genetic mitochondrial disorder that robs the body’s cells of energy, in turn causing progressive multiple organ dysfunction and failure”.
“Frederik’s last question to me, before his other remarks, was: ‘Papa, are you proud of me?’ He had barely been able to speak for several days,” the heartfelt statement continued.

“As his siblings and most anyone who ever met him say, ‘Frederik is the strongest person that we know!’ Frederik fought his disease valiantly until the very end.”
Here’s everything to know about the late prince’s older siblings, Princess Charlotte and Prince Alexandre.